The Hatter Cardiovascular Institute

2025

An activator of phosphatidylinositol 3-kinase alpha restores cardioprotection from ischaemia/reperfusion injury in mice with coronary atherosclerosis or insulin resistance.

Golforoush P., Sulaiman E., He D., Yellon D., Davidson S.

Cardiovascular research, 2025

Importance of basic science and research training for the future generation of cardiologists.

Chiva-Blanch G., Liehn E., Andreadou I., Barc J., Brundel B., Davidson S., Elliott P., Evans P., Giricz Z., Gladka M., Gollmann-Tepeköylü C., Kleinbongard P., Krieg T., Linde C., Lüscher T., Guzik T., Maguy A., McDonagh T., Paillard M., Parma R., Pesce M., Pompilio G., Rubini M., Streckfuss-Bömeke K., Thielmann M., Tocchetti C., Van Linthout S., Vardas P., Vranckx P., Wojta J., Perrino C.

European heart journal, 2025

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function.

Paillard M., Abdellatif M., Andreadou I., Bär C., Bertrand L., Brundel B., Chiva-Blanch G., Davidson S., Dawson D., Di Lisa F., Evans P., Giricz Z., Hausenloy D., Kleinbongard P., Lezoualc'h F., Liehn E., Maack C., Maguy A., Murphy E., Perrino C., Pesce M., Rainer P., Streckfuss-Bömeke K., Thielmann M., Tian R., Tocchetti C., Van Der Velden J., Van Linthout S., Zacchigna S., Krieg T.

European journal of heart failure, 2025

The contribution of cardiomyocyte hypercontracture to the burden of acute myocardial infarction: an update.

Yusof N., Yellon D., Davidson S.

Basic research in cardiology, 2025

Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC.

Davidson S., Andreadou I., Antoniades C., Bartunek J., Basso C., Brundel B., Byrne R., Chiva-Blanch G., da Costa Martins P., Evans P., Girão H., Giricz Z., Gollmann-Tepeköylü C., Guzik T., Gyöngyösi M., Hübner N., Joner M., Kleinbongard P., Krieg T., Liehn E., Madonna R., Maguy A., Paillard M., Pesce M., Petersen S., Schiattarella G., Sluijter J., Steffens S., Streckfuss-Bömeke K., Thielmann M., Tucker A., Van Linthout S., Wijns W., Wojta J., Wu J., Perrino C.

Cardiovascular research, 2025

A cautionary note on the potential pitfalls of using N-terminal truncated CD63 to label small extracellular vesicles.

Sulaiman E., Yellon D., Davidson S.

Scientific reports, 2025

SGLT2 inhibitors for prevention and management of cancer treatment-related cardiovascular toxicity: a review of potential mechanisms and clinical insights.

Simela C., Walker J., Ghosh A., Chen D.

Cardio-oncology (London, England), 2025

HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related cardiac dysfunction.

Dowsing B., Dehbi H., Chung R., Pedra J., Worn O., Artico J., Schmid P., Roylance R., Kellman P., Moon J., Crake T., Westwood M., Ghosh A., Andres M., Nazir M., Lyon A., Chen D., Walker M., Manisty C.

BMJ open, 2025

SGLT2 Inhibition Induces Cardioprotection by Increasing Parasympathetic Activity.

Basalay M., Korsak A., He Z., Gourine A., Davidson S., Yellon D.

Circulation research, 2025

Novel Selective Cardiac Myosin-Targeted Inhibitors Alleviate Myocardial Ischaemia-Reperfusion Injury.

Yusof N., Yellon D., Davidson S.

Cardiovascular drugs and therapy, 2025

2024

Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes.

Beikoghli Kalkhoran S., Basalay M., He Z., Golforoush P., Roper T., Caplin B., Salama A., Davidson S., Yellon D.

Basic research in cardiology, 2024

SGLT1 contributes to glucose-mediated exacerbation of ischemia-reperfusion injury in ex vivo rat heart.

Almalki A., Arjun S., Harding I., Jasem H., Kolatsi-Joannou M., Jafree D., Pomeranz G., Long D., Yellon D., Bell R.

Basic research in cardiology, 2024

The ESC Working Group on Cellular Biology of the Heart.

Perrino C., Pesce M., Davidson S.

European heart journal, 2024

Effect of Remote Ischaemic Conditioning on the Inflammatory Cytokine Cascade of COVID-19 (RIC in COVID-19): a Randomized Controlled Trial.

Lukhna K., do Carmo H., Castillo A., Davidson S., Geffen H., Giesz S., Golforoush P., Bovi T., Gorag D., Salama A., Imamdin A., Kalkhoran S., Lecour S., Perroud M., Ntsekhe M., Sposito A., Yellon D.

Cardiovascular drugs and therapy, 2024

Metabolic Considerations in Direct Procurement and Perfusion Protocols with DCD Heart Transplantation.

Arnold M., Do P., Davidson S., Large S., Helmer A., Beer G., Siepe M., Longnus S.

International journal of molecular sciences, 2024

Mechanisms underlying exercise intolerance in long COVID: An accumulation of multisystem dysfunction.

Jamieson A., Al Saikhan L., Alghamdi L., Hamill Howes L., Purcell H., Hillman T., Heightman M., Treibel T., Orini M., Bell R., Scully M., Hamer M., Chaturvedi N., Montgomery H., Hughes A., Astin R., Jones S.

Physiological reports, 2024

Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study.

Carmo H., Castillo A., Bonilha I., Gomes E., Barreto J., Moura F., Davanzo G., de Brito Monteiro L., Muraro S., Fabiano de Souza G., Morari J., Galdino F., Brunetti N., Reis-de-Oliveira G., Carregari V., Nadruz W., Martins-de-Souza D., Farias A., Velloso L., Proenca-Modena J., Mori M., Loh W., Bhatt D., Yellon D., Davidson S., De Oliveira P., Moraes-Vieira P., Sposito A.

Frontiers in pharmacology, 2024

2023

Hydrolytic Activity of Mitochondrial F

Nikolaou P., Lambrinidis G., Georgiou M., Karagiannis D., Efentakis P., Bessis-Lazarou P., Founta K., Kampoukos S., Konstantin V., Palmeira C., Davidson S., Lougiakis N., Marakos P., Pouli N., Mikros E., Andreadou I.

Journal of medicinal chemistry, 2023

Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection.

Heusch G., Andreadou I., Bell R., Bertero E., Botker H., Davidson S., Downey J., Eaton P., Ferdinandy P., Gersh B., Giacca M., Hausenloy D., Ibanez B., Krieg T., Maack C., Schulz R., Sellke F., Shah A., Thiele H., Yellon D., Di Lisa F.

Redox biology, 2023

Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay.

Horvath C., Jarabicova I., Kura B., Kalocayova B., Faurobert E., Davidson S., Adameova A.

Biochimica et biophysica acta. Molecular cell research, 2023

Remote Ischemic Conditioning: Challenges and Opportunities.

Zhao W., Hausenloy D., Hess D., Yellon D., Ji X.

Stroke, 2023

Defining Peri-Operative Myocardial Injury during Cardiac Surgery Using High-Sensitivity Troponin T.

Sharma V., Zheng H., Candilio L., Nicholas J., Clayton T., Yellon D., Bulluck H., Hausenloy D.

Journal of clinical medicine, 2023

Anthracyclines and Biomarkers of Myocardial Injury: The Effect of Remote Ischemic Conditioning.

Mallouppas M., Chung R., Ghosh A., Macklin A., Yellon D., Walker J.

JACC. CardioOncology, 2023

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

Gong G., Bilanges B., Allsop B., Masson G., Roberton V., Askwith T., Oxenford S., Madsen R., Conduit S., Bellini D., Fitzek M., Collier M., Najam O., He Z., Wahab B., McLaughlin S., Chan A., Feierberg I., Madin A., Morelli D., Bhamra A., Vinciauskaite V., Anderson K., Surinova S., Pinotsis N., Lopez-Guadamillas E., Wilcox M., Hooper A., Patel C., Whitehead M., Bunney T., Stephens L., Hawkins P., Katan M., Yellon D., Davidson S., Smith D., Phillips J., Angell R., Williams R., Vanhaesebroeck B.

Nature, 2023

The RISK pathway leading to mitochondria and cardioprotection: how everything started.

Yellon D., Beikoghli Kalkhoran S., Davidson S.

Basic research in cardiology, 2023

Remote Ischaemic Conditioning in STEMI Patients in Sub-Saharan AFRICA: Rationale and Study Design for the RIC-AFRICA Trial.

Lukhna K., Hausenloy D., Ali A., Bajaber A., Calver A., Mutyaba A., Mohamed A., Kiggundu B., Chishala C., Variava E., Elmakki E., Ogola E., Hamid E., Okello E., Gaafar I., Mwazo K., Makotoko M., Naidoo M., Abdelhameed M., Badri M., van der Schyff N., Abozaid O., Xafis P., Giesz S., Gould T., Welgemoed W., Walker M., Ntsekhe M., Yellon D.

Cardiovascular drugs and therapy, 2023

Long COVID and the cardiovascular system-elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases.

Gyöngyösi M., Alcaide P., Asselbergs F., Brundel B., Camici G., Martins P., Ferdinandy P., Fontana M., Girao H., Gnecchi M., Gollmann-Tepeköylü C., Kleinbongard P., Krieg T., Madonna R., Paillard M., Pantazis A., Perrino C., Pesce M., Schiattarella G., Sluijter J., Steffens S., Tschöpe C., Van Linthout S., Davidson S.

Cardiovascular research, 2023

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles.

Davidson S., Boulanger C., Aikawa E., Badimon L., Barile L., Binder C., Brisson A., Buzas E., Emanueli C., Jansen F., Katsur M., Lacroix R., Lim S., Mackman N., Mayr M., Menasché P., Nieuwland R., Sahoo S., Takov K., Thum T., Vader P., Wauben M., Witwer K., Sluijter J.

Cardiovascular research, 2023

Nicorandil - an Effective Multitarget Drug for Cardioprotection?

Pearce L., Carr R., Yellon D., Davidson S.

Cardiovascular drugs and therapy, 2023

Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications.

Heuts S., Gollmann-Tepeköylü C., Denessen E., Olsthoorn J., Romeo J., Maessen J., van 't Hof A., Bekers O., Hammarsten O., Pölzl L., Holfeld J., Bonaros N., van der Horst I., Davidson S., Thielmann M., Mingels A.

European heart journal, 2023

Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning.

Ferdinandy P., Andreadou I., Baxter G., Bøtker H., Davidson S., Dobrev D., Gersh B., Heusch G., Lecour S., Ruiz-Meana M., Zuurbier C., Hausenloy D., Schulz R.

Pharmacological reviews, 2023

2022

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart.

van der Velden J., Asselbergs F., Bakkers J., Batkai S., Bertrand L., Bezzina C., Bot I., Brundel B., Carrier L., Chamuleau S., Ciccarelli M., Dawson D., Davidson S., Dendorfer A., Duncker D., Eschenhagen T., Fabritz L., Falcão-Pires I., Ferdinandy P., Giacca M., Girao H., Gollmann-Tepeköylü C., Gyongyosi M., Guzik T., Hamdani N., Heymans S., Hilfiker A., Hilfiker-Kleiner D., Hoekstra A., Hulot J., Kuster D., van Laake L., Lecour S., Leiner T., Linke W., Lumens J., Lutgens E., Madonna R., Maegdefessel L., Mayr M., van der Meer P., Passier R., Perbellini F., Perrino C., Pesce M., Priori S., Remme C., Rosenhahn B., Schotten U., Schulz R., Sipido K., Sluijter J., van Steenbeek F., Steffens S., Terracciano C., Tocchetti C., Vlasman P., Yeung K., Zacchigna S., Zwaagman D., Thum T.

Cardiovascular research, 2022

Do We Really Need Aspirin Loading for STEMI?

Ye R., Jneid H., Alam M., Uretsky B., Atar D., Kitakaze M., Davidson S., Yellon D., Birnbaum Y.

Cardiovascular drugs and therapy, 2022

Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation.

Hall A., Karwi Q., Kumar S., Dongworth R., Aksentijević D., Altamimi T., Fridianto K., Chinda K., Hernandez-Resendiz S., Mahmood M., Michelakis E., Ramachandra C., Ching J., Vicencio J., Shattock M., Kovalik J., Yellon D., Lopaschuk G., Hausenloy D.

Scientific reports, 2022

From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22.

Evans P., Davidson S., Wojta J., Bäck M., Bollini S., Brittan M., Catapano A., Chaudhry B., Cluitmans M., Gnecchi M., Guzik T., Hoefer I., Madonna R., Monteiro J., Morawietz H., Osto E., Padró T., Sluimer J., Tocchetti C., Van der Heiden K., Vilahur G., Waltenberger J., Weber C.

Cardiovascular research, 2022

Hydrogen-Bonded Water-Aminium Assemblies for Synthesis of Zeotypes with Ordered Heteroatoms.

Park S., Radhakrishnan S., Choi W., Chandran C., Kemp K., Breynaert E., Bell R., Kirschhock C., Hong S.

Journal of the American Chemical Society, 2022

Correction to: RIC in COVID-19-a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19.

Davidson S., Lukhna K., Gorog D., Salama A., Castillo A., Giesz S., Golforoush P., Kalkhoran S., Lecour S., Imamdin A., do Carmo H., Bovi T., Perroud M., Ntsekhe M., Sposito A., Yellon D.

Cardiovascular drugs and therapy, 2022

RIC in COVID-19-a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19.

Davidson S., Lukhna K., Gorog D., Salama A., Castillo A., Giesz S., Golforoush P., Kalkhoran S., Lecour S., Imamdin A., do Carmo H., Bovi T., Perroud M., Ntsekhe M., Sposito A., Yellon D.

Cardiovascular drugs and therapy, 2022

Opioids in Acute Coronary Syndromes: Friend or Foe?

Basalay M., Yellon D., Davidson S.

Cardiovascular drugs and therapy, 2022

Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart.

Lecour S., Du Pré B., Bøtker H., Brundel B., Daiber A., Davidson S., Ferdinandy P., Girao H., Gollmann-Tepeköylü C., Gyöngyösi M., Hausenloy D., Madonna R., Marber M., Perrino C., Pesce M., Schulz R., Sluijter J., Steffens S., Van Linthout S., Young M., Van Laake L.

Cardiovascular research, 2022

Extracellular vesicles signal from bones to vessels: an answer to the 'calcification paradox'?

Chiva-Blanch G., Davidson S.

Cardiovascular research, 2022

Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis.

Prasannan N., Heightman M., Hillman T., Wall E., Bell R., Kessler A., Neave L., Doyle A., Devaraj A., Singh D., Dehbi H., Scully M.

Blood advances, 2022

Negative interaction between nitrates and remote ischemic preconditioning in patients undergoing cardiac surgery: the ERIC-GTN and ERICCA studies.

Hamarneh A., Ho A., Bulluck H., Sivaraman V., Ricciardi F., Nicholas J., Shanahan H., Hardman E., Wicks P., Ramlall M., Chung R., McGowan J., Cordery R., Lawrence D., Clayton T., Kyle B., Xenou M., Ariti C., Yellon D., Hausenloy D.

Basic research in cardiology, 2022

Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure.

Godec T., Bromage D., Pujades-Rodriguez M., Cannatà A., Gonzalez-Izquierdo A., Denaxas S., Hemingway H., Shah A., Yellon D., McDonagh T.

ESC heart failure, 2022

Extracellular histones are a target in myocardial ischaemia-reperfusion injury.

Shah M., He Z., Rauf A., Beikoghli Kalkhoran S., Heiestad C., Stensløkken K., Parish C., Soehnlein O., Arjun S., Davidson S., Yellon D.

Cardiovascular research, 2022

2021

Post-COVID-19 assessment in a specialist clinical service: a 12-month, single-centre, prospective study in 1325 individuals.

Heightman M., Prashar J., Hillman T., Marks M., Livingston R., Ridsdale H., Bell R., Zandi M., McNamara P., Chauhan A., Denneny E., Astin R., Purcell H., Attree E., Hishmeh L., Prescott G., Evans R., Mehta P., Brennan E., Brown J., Porter J., Logan S., Wall E., Dehbi H., Cone S., Banerjee A.

BMJ open respiratory research, 2021

Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy.

Francis R., Chong J., Ramlall M., Bucciarelli-Ducci C., Clayton T., Dodd M., Engstrøm T., Evans R., Ferreira V., Fontana M., Greenwood J., Kharbanda R., Kim W., Kotecha T., Lønborg J., Mathur A., Møller U., Moon J., Perkins A., Rakhit R., Yellon D., Bøtker H., Bulluck H., Hausenloy D.

Basic research in cardiology, 2021

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action.

Lecour S., Andreadou I., Bøtker H., Davidson S., Heusch G., Ruiz-Meana M., Schulz R., Zuurbier C., Ferdinandy P., Hausenloy D.

Basic research in cardiology, 2021

COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart.

Pesce M., Agostoni P., Bøtker H., Brundel B., Davidson S., Caterina R., Ferdinandy P., Girao H., Gyöngyösi M., Hulot J., Lecour S., Perrino C., Schulz R., Sluijter J., Steffens S., Tancevski I., Gollmann-Tepeköylü C., Tschöpe C., Linthout S., Madonna R.

Cardiovascular research, 2021

Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart.

Davidson S., Padró T., Bollini S., Vilahur G., Duncker D., Evans P., Guzik T., Hoefer I., Waltenberger J., Wojta J., Weber C.

Cardiovascular research, 2021

Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions: a Consensus Document of the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI).

Bulluck H., Paradies V., Barbato E., Baumbach A., Bøtker H., Capodanno D., De Caterina R., Cavallini C., Davidson S., Feldman D., Ferdinandy P., Gili S., Gyöngyösi M., Kunadian V., Ooi S., Madonna R., Marber M., Mehran R., Ndrepepa G., Perrino C., Schüpke S., Silvain J., Sluijter J., Tarantini G., Toth G., Van Laake L., von Birgelen C., Zeitouni M., Jaffe A., Thygesen K., Hausenloy D.

European heart journal, 2021

Myocardial Viability Imaging using Manganese-Enhanced MRI in the First Hours after Myocardial Infarction.

Jasmin N., Thin M., Johnson R., Jackson L., Roberts T., David A., Lythgoe M., Yang P., Davidson S., Camelliti P., Stuckey D.

Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021

Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance.

Kotecha T., Knight D., Razvi Y., Kumar K., Vimalesvaran K., Thornton G., Patel R., Chacko L., Brown J., Coyle C., Leith D., Shetye A., Ariff B., Bell R., Captur G., Coleman M., Goldring J., Gopalan D., Heightman M., Hillman T., Howard L., Jacobs M., Jeetley P., Kanagaratnam P., Kon O., Lamb L., Manisty C., Mathurdas P., Mayet J., Negus R., Patel N., Pierce I., Russell G., Wolff A., Xue H., Kellman P., Moon J., Treibel T., Cole G., Fontana M.

European heart journal, 2021

Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.

Nizari S., Basalay M., Chapman P., Korte N., Korsak A., Christie I., Theparambil S., Davidson S., Reimann F., Trapp S., Yellon D., Gourine A.

Basic research in cardiology, 2021

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.

Gimona M., Brizzi M., Choo A., Dominici M., Davidson S., Grillari J., Hermann D., Hill A., de Kleijn D., Lai R., Lai C., Lim R., Monguió-Tortajada M., Muraca M., Ochiya T., Ortiz L., Toh W., Yi Y., Witwer K., Giebel B., Lim S.

Cytotherapy, 2021

Noninvasive rapid cardiac magnetic resonance for the assessment of cardiomyopathies in low-middle income countries.

Menacho Medina K., Seraphim A., Katekaru D., Abdel-Gadir A., Han Y., Westwood M., Walker J., Moon J., Herrey A.

Expert review of cardiovascular therapy, 2021

Exosomes from neuronal stem cells may protect the heart from ischaemia/reperfusion injury via JAK1/2 and gp130.

Katsur M., He Z., Vinokur V., Corteling R., Yellon D., Davidson S.

Journal of cellular and molecular medicine, 2021

Benefit of Extracellular Vesicles at the Blood-Brain Barrier.

Davidson S.

Arteriosclerosis, thrombosis, and vascular biology, 2021

Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response.

Pearce L., Davidson S., Yellon D.

Basic research in cardiology, 2021

Effect of remote ischaemic conditioning on platelet reactivity and endogenous fibrinolysis in ST-elevation myocardial infarction: a substudy of the CONDI-2/ERIC-PPCI randomized controlled trial.

Gorog D., Farag M., Spinthakis N., Yellon D., Bøtker H., Kharbanda R., Hausenloy D.

Cardiovascular research, 2021

Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart.

Perrino C., Ferdinandy P., Bøtker H., Brundel B., Collins P., Davidson S., den Ruijter H., Engel F., Gerdts E., Girao H., Gyöngyösi M., Hausenloy D., Lecour S., Madonna R., Marber M., Murphy E., Pesce M., Regitz-Zagrosek V., Sluijter J., Steffens S., Gollmann-Tepeköylü C., Van Laake L., Van Linthout S., Schulz R., Ytrehus K.

Cardiovascular research, 2021

A Computationally Efficient Approach to Segmentation of the Aorta and Coronary Arteries Using Deep Learning.

Cheung W., Bell R., Nair A., Menezes L., Patel R., Wan S., Chou K., Chen J., Torii R., Davies R., Moon J., Alexander D., Jacob J.

IEEE access : practical innovations, open solutions, 2021

Myocardial Perfusion Imaging After Severe COVID-19 Infection Demonstrates Regional Ischemia Rather Than Global Blood Flow Reduction.

Thornton G., Shetye A., Knight D., Knott K., Artico J., Kurdi H., Yousef S., Antonakaki D., Razvi Y., Chacko L., Brown J., Patel R., Vimalesvaran K., Seraphim A., Davies R., Xue H., Kotecha T., Bell R., Manisty C., Cole G., Moon J., Kellman P., Fontana M., Treibel T.

Frontiers in cardiovascular medicine, 2021

2020

Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols.

Penna C., Andreadou I., Aragno M., Beauloye C., Bertrand L., Lazou A., Falcão-Pires I., Bell R., Zuurbier C., Pagliaro P., Hausenloy D.

British journal of pharmacology, 2020

Mouse models of atherosclerosis and their suitability for the study of myocardial infarction.

Golforoush P., Yellon D., Davidson S.

Basic research in cardiology, 2020

The importance of clinically relevant background therapy in cardioprotective studies.

He Z., Davidson S., Yellon D.

Basic research in cardiology, 2020

Hypertensive Cardiotoxicity in Cancer Treatment-Systematic Analysis of Adjunct, Conventional Chemotherapy, and Novel Therapies-Epidemiology, Incidence, and Pathophysiology.

Chung R., Tyebally S., Chen D., Kapil V., Walker J., Addison D., Ismail-Khan R., Guha A., Ghosh A.

Journal of clinical medicine, 2020

Neuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study.

Basalay M., Wiart M., Chauveau F., Dumot C., Leon C., Amaz C., Bolbos R., Cash D., Kim E., Mechtouff L., Cho T., Nighoghossian N., Davidson S., Ovize M., Yellon D.

Scientific reports, 2020

Can glucagon-like peptide-1 (GLP-1) analogues make neuroprotection a reality?

Basalay M., Davidson S., Yellon D.

Neural regeneration research, 2020

Cardio-oncology for the general physician: 'old' and 'new' cardiovascular toxicities and how to manage them.

Mallouppas M., Walker J., Guha A., Dobson R., Ghosh A.

British journal of hospital medicine (London, England : 2005), 2020

The cytokine storm of COVID-19: a spotlight on prevention and protection.

Pearce L., Davidson S., Yellon D.

Expert opinion on therapeutic targets, 2020

3D-3D topotactic transformation in aluminophosphate molecular sieves and its implication in new zeolite structure generation.

Huang Z., Seo S., Shin J., Wang B., Bell R., Hong S., Zou X.

Nature communications, 2020

SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models.

Andreadou I., Bell R., Bøtker H., Zuurbier C.

Biochimica et biophysica acta. Molecular basis of disease, 2020

Professor Lionel H. Opie 6th May 1933-20th February 2020.

Gersh B., Yellon D.

European heart journal, 2020

A future for remote ischaemic conditioning in high-risk patients.

Hausenloy D., Ntsekhe M., Yellon D.

Basic research in cardiology, 2020

Increased production of functional small extracellular vesicles in senescent endothelial cells.

Riquelme J., Takov K., Santiago-Fernández C., Rossello X., Lavandero S., Yellon D., Davidson S.

Journal of cellular and molecular medicine, 2020

Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury.

Davidson S., Adameová A., Barile L., Cabrera-Fuentes H., Lazou A., Pagliaro P., Stensløkken K., Garcia-Dorado D.

Journal of cellular and molecular medicine, 2020

Small extracellular vesicles secreted from human amniotic fluid mesenchymal stromal cells possess cardioprotective and promigratory potential.

Takov K., He Z., Johnston H., Timms J., Guillot P., Yellon D., Davidson S.

Basic research in cardiology, 2020

CAR T Cell Therapy-Related Cardiovascular Outcomes and Management: Systemic Disease or Direct Cardiotoxicity?

Ghosh A., Chen D., Guha A., Mackenzie S., Walker J., Roddie C.

JACC. CardioOncology, 2020

Thromboembolic risk with IVIg: Incidence and risk factors in patients with inflammatory neuropathy.

Kapoor M., Spillane J., Englezou C., Sarri-Gonzalez S., Bell R., Rossor A., Manji H., Reilly M., Lunn M., Carr A.

Neurology, 2020

The Role of Extracellular DNA and Histones in Ischaemia-Reperfusion Injury of the Myocardium.

Shah M., Yellon D., Davidson S.

Cardiovascular drugs and therapy, 2020

Para-caval leiomyosarcoma invading the right heart.

Jozsa C., Cheasty E., Bingcang J., Walker J., Shah C., Bhattacharyya S., Ghosh A.

Journal of cardiovascular computed tomography, 2020

2019

Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study.

Bromage D., Godec T., Pujades-Rodriguez M., Gonzalez-Izquierdo A., Denaxas S., Hemingway H., Yellon D.

Cardiovascular diabetology, 2019

Preventing the Cancer Patient of Today From Becoming the Heart Failure Patient of Tomorrow.

Yellon D., Walker J., Arjun S.

JACC. CardioOncology, 2019

Neuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues-Liraglutide and Semaglutide.

Basalay M., Davidson S., Yellon D.

Cardiovascular drugs and therapy, 2019

David Garcia-Dorado: a true pioneer in cardiac ischaemia/reperfusion injury.

Hausenloy D., Davidson S.

Cardiovascular research, 2019

Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel.

Davidson S., Szabadkai G., Duchen M.

Cell calcium, 2019

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

Hausenloy D., Kharbanda R., Møller U., Ramlall M., Aarøe J., Butler R., Bulluck H., Clayton T., Dana A., Dodd M., Engstrom T., Evans R., Lassen J., Christensen E., Garcia-Ruiz J., Gorog D., Hjort J., Houghton R., Ibanez B., Knight R., Lippert F., Lønborg J., Maeng M., Milasinovic D., More R., Nicholas J., Jensen L., Perkins A., Radovanovic N., Rakhit R., Ravkilde J., Ryding A., Schmidt M., Riddervold I., Sørensen H., Stankovic G., Varma M., Webb I., Terkelsen C., Greenwood J., Yellon D., Bøtker H.

Lancet (London, England), 2019

SGLT2 inhibitors: reviving the sodium-hydrogen exchanger cardioprotection hypothesis?

Arjun S., Bell R.

Cardiovascular research, 2019

Circulating blood cells and extracellular vesicles in acute cardioprotection.

Davidson S., Andreadou I., Barile L., Birnbaum Y., Cabrera-Fuentes H., Cohen M., Downey J., Girao H., Pagliaro P., Penna C., Pernow J., Preissner K., Ferdinandy P.

Cardiovascular research, 2019

Shining the spotlight on cardioprotection: beyond the cardiomyocyte.

Davidson S., Andreadou I., Garcia-Dorado D., Hausenloy D.

Cardiovascular research, 2019

Innate immunity as a target for acute cardioprotection.

Zuurbier C., Abbate A., Cabrera-Fuentes H., Cohen M., Collino M., De Kleijn D., Downey J., Pagliaro P., Preissner K., Takahashi M., Davidson S.

Cardiovascular research, 2019

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.

Hausenloy D., Chilian W., Crea F., Davidson S., Ferdinandy P., Garcia-Dorado D., van Royen N., Schulz R., Heusch G.

Cardiovascular research, 2019

Atrial fibrillation and stroke: a practical guide.

Best J., Bell R., Haque M., Chandratheva A., Werring D.

Practical neurology, 2019

FAM3A - A mitochondrial route to the stimulation of angiogenesis?

Davidson S.

EBioMedicine, 2019

ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure.

Madonna R., Van Laake L., Botker H., Davidson S., De Caterina R., Engel F., Eschenhagen T., Fernandez-Aviles F., Hausenloy D., Hulot J., Lecour S., Leor J., Menasché P., Pesce M., Perrino C., Prunier F., Van Linthout S., Ytrehus K., Zimmermann W., Ferdinandy P., Sluijter J.

Cardiovascular research, 2019

Stromal cell-derived factor-1α signals via the endothelium to protect the heart against ischaemia-reperfusion injury.

Bromage D., Taferner S., He Z., Ziff O., Yellon D., Davidson S.

Journal of molecular and cellular cardiology, 2019

SGLT2 Inhibitor, Canagliflozin, Attenuates Myocardial Infarction in the Diabetic and Nondiabetic Heart.

Lim V., Bell R., Arjun S., Kolatsi-Joannou M., Long D., Yellon D.

JACC. Basic to translational science, 2019

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week.

Davidson S., Ferdinandy P., Andreadou I., Bøtker H., Heusch G., Ibáñez B., Ovize M., Schulz R., Yellon D., Hausenloy D., Garcia-Dorado D.

Journal of the American College of Cardiology, 2019

Comparison of small extracellular vesicles isolated from plasma by ultracentrifugation or size-exclusion chromatography: yield, purity and functional potential.

Takov K., Yellon D., Davidson S.

Journal of extracellular vesicles, 2019

2018

Protection From Cardiac Ischemia-Reperfusion Injury by Epigenetic Regulation of NADPH Oxidase.

Davidson S., Yellon D.

Circulation, 2018

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning.

Davidson S., Riquelme J., Zheng Y., Vicencio J., Lavandero S., Yellon D.

Scientific reports, 2018

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection-evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology.

Davidson S., Arjun S., Basalay M., Bell R., Bromage D., Bøtker H., Carr R., Cunningham J., Ghosh A., Heusch G., Ibanez B., Kleinbongard P., Lecour S., Maddock H., Ovize M., Walker M., Wiart M., Yellon D.

Basic research in cardiology, 2018

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.

Bøtker H., Hausenloy D., Andreadou I., Antonucci S., Boengler K., Davidson S., Deshwal S., Devaux Y., Di Lisa F., Di Sante M., Efentakis P., Femminò S., García-Dorado D., Giricz Z., Ibanez B., Iliodromitis E., Kaludercic N., Kleinbongard P., Neuhäuser M., Ovize M., Pagliaro P., Rahbek-Schmidt M., Ruiz-Meana M., Schlüter K., Schulz R., Skyschally A., Wilder C., Yellon D., Ferdinandy P., Heusch G.

Basic research in cardiology, 2018

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.

Monypenny J., Milewicz H., Flores-Borja F., Weitsman G., Cheung A., Chowdhury R., Burgoyne T., Arulappu A., Lawler K., Barber P., Vicencio J., Keppler M., Wulaningsih W., Davidson S., Fraternali F., Woodman N., Turmaine M., Gillett C., Franz D., Quezada S., Futter C., Von Kriegsheim A., Kolch W., Vojnovic B., Carlton J., Ng T.

Cell reports, 2018

Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects.

Basalay M., Davidson S., Gourine A., Yellon D.

Basic research in cardiology, 2018

Ischaemic Preconditioning Protects Cardiomyocytes from Anthracycline-Induced Toxicity via the PI3K Pathway.

Maulik A., Davidson S., Piotrowska I., Walker M., Yellon D.

Cardiovascular drugs and therapy, 2018

SGLT2 inhibitors: hypotheses on the mechanism of cardiovascular protection.

Bell R., Yellon D.

The lancet. Diabetes & endocrinology, 2018

Molecular dynamics study of tridymite.

Takada A., Glaser K., Bell R., Catlow C.

IUCrJ, 2018

Cardioprotection - is no the answer? A renewed look at nitric oxide signalling in cardiomyocytes.

Davidson S., Yellon D.

Cardiovascular research, 2018

The GTN patch: a simple and effective new approach to cardioprotection?

Yellon D., He Z., Khambata R., Ahluwalia A., Davidson S.

Basic research in cardiology, 2018

Myocardial Infarct Size Reduction Provided by Local and Remote Ischaemic Preconditioning: References Values from the Hatter Cardiovascular Institute.

Rossello X., He Z., Yellon D.

Cardiovascular drugs and therapy, 2018

The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway.

Do Carmo H., Arjun S., Petrucci O., Yellon D., Davidson S.

Cardiovascular drugs and therapy, 2018

Exosomes and cardioprotection - A critical analysis.

Davidson S., Yellon D.

Molecular aspects of medicine, 2018

Therapeutic strategies utilizing SDF-1α in ischaemic cardiomyopathy.

Ziff O., Bromage D., Yellon D., Davidson S.

Cardiovascular research, 2018

Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion.

Rossello X., Riquelme J., Davidson S., Yellon D.

Journal of cellular and molecular medicine, 2018

Biologically active constituents of the secretome of human W8B2

Nie S., Wang X., Sivakumaran P., Chong M., Liu X., Karnezis T., Bandara N., Takov K., Nowell C., Wilcox S., Shambrook M., Hill A., Harris N., Newcomb A., Strappe P., Shayan R., Hernández D., Clarke J., Hanssen E., Davidson S., Dusting G., Pébay A., Ho J., Williamson N., Lim S.

Scientific reports, 2018

The RISK pathway and beyond.

Rossello X., Yellon D.

Basic research in cardiology, 2018

Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single- or Two-Photon Confocal Microscopy.

Davidson S., Duchen M.

Methods in molecular biology (Clifton, N.J.), 2018

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology.

Sluijter J., Davidson S., Boulanger C., Buzás E., de Kleijn D., Engel F., Giricz Z., Hausenloy D., Kishore R., Lecour S., Leor J., Madonna R., Perrino C., Prunier F., Sahoo S., Schiffelers R., Schulz R., Van Laake L., Ytrehus K., Ferdinandy P.

Cardiovascular research, 2018

Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro.

Davidson S., Riquelme J., Takov K., Vicencio J., Boi-Doku C., Khoo V., Doreth C., Radenkovic D., Lavandero S., Yellon D.

Journal of cellular and molecular medicine, 2018

2017

Xenon: A Noble Member of the Cardioprotection Club.

Yellon D., Rossello X.

Journal of the American College of Cardiology, 2017

New insights into cardiotoxicity caused by chemotherapeutic agents.

Grieve D., Davidson S.

British journal of pharmacology, 2017

The role of PI3Kα isoform in cardioprotection.

Rossello X., Riquelme J., He Z., Taferner S., Vanhaesebroeck B., Davidson S., Yellon D.

Basic research in cardiology, 2017

Ventilation strategy has a major influence on remote ischaemic preconditioning in mice.

Davidson S., He Z., Dyson A., Bromage D., Yellon D.

Journal of cellular and molecular medicine, 2017

Combination Therapy to Target Reperfusion Injury After ST-Segment-Elevation Myocardial Infarction: A More Effective Approach to Cardioprotection.

Hausenloy D., Yellon D.

Circulation, 2017

Melatonin as a cardioprotective therapy following ST-segment elevation myocardial infarction: is it really promising? Reply.

Hausenloy D., Garcia-Dorado D., Erik Bøtker H., Davidson S., Downey J., Engel F., Jennings R., Lecour S., Leor J., Madonna R., Ovize M., Perrino C., Prunier F., Schulz R., Sluijter J., Van Laake L., Vinten-Johansen J., Yellon D., Ytrehus K., Heusch G., Ferdinandy P.

Cardiovascular research, 2017

Diagnostic performance of T

Bulluck H., Rosmini S., Abdel-Gadir A., Bhuva A., Treibel T., Fontana M., Gonzalez-Lopez E., Ramlall M., Hamarneh A., Sirker A., Herrey A., Manisty C., Yellon D., Moon J., Hausenloy D.

Journal of magnetic resonance imaging : JMRI, 2017

Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography.

Beikoghli Kalkhoran S., Hall A., White I., Cooper J., Fan Q., Ong S., Hernández-Reséndiz S., Cabrera-Fuentes H., Chinda K., Chakraborty B., Dorn G., Yellon D., Hausenloy D.

Physiological reports, 2017

Neutrophil gelatinase-associated lipocalin prior to cardiac surgery predicts acute kidney injury and mortality.

Bulluck H., Maiti R., Chakraborty B., Candilio L., Clayton T., Evans R., Jenkins D., Kolvekar S., Kunst G., Laing C., Nicholas J., Pepper J., Yellon D., Hausenloy D.

Heart (British Cardiac Society), 2017

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.

Perrino C., Barabási A., Condorelli G., Davidson S., De Windt L., Dimmeler S., Engel F., Hausenloy D., Hill J., Van Laake L., Lecour S., Leor J., Madonna R., Mayr M., Prunier F., Sluijter J., Schulz R., Thum T., Ytrehus K., Ferdinandy P.

Cardiovascular research, 2017

Letter by Takov et al Regarding Article, "Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice".

Takov K., Yellon D., Davidson S.

Circulation research, 2017

Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance.

Dongworth R., Campbell-Washburn A., Cabrera-Fuentes H., Bulluck H., Roberts T., Price A., Hernández-Reséndiz S., Ordidge R., Thomas D., Yellon D., Lythgoe M., Hausenloy D.

Scientific reports, 2017

Reply to "Circadian variation in acute myocardial infarction size: Likely involvement of the melatonin and suprachiasmatic nuclei".

Bulluck H., Nicholas J., Crimi G., White S., Ludman A., Pica S., Raineri C., Cabrera-Fuentes H., Yellon D., Rodriguez-Palomares J., Garcia-Dorado D., Hausenloy D.

International journal of cardiology, 2017

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.

Hausenloy D., Garcia-Dorado D., Bøtker H., Davidson S., Downey J., Engel F., Jennings R., Lecour S., Leor J., Madonna R., Ovize M., Perrino C., Prunier F., Schulz R., Sluijter J., Van Laake L., Vinten-Johansen J., Yellon D., Ytrehus K., Heusch G., Ferdinandy P.

Cardiovascular research, 2017

Remote Ischaemic Conditioning in Carotid Artery Stenting: Another Step on the Journey Toward Clinical Translatability?

Bell R., Yellon D.

Circulation, 2017

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations.

Hausenloy D., Botker H., Engstrom T., Erlinge D., Heusch G., Ibanez B., Kloner R., Ovize M., Yellon D., Garcia-Dorado D.

European heart journal, 2017

Exosomes and Cardiovascular Protection.

Davidson S., Takov K., Yellon D.

Cardiovascular drugs and therapy, 2017

A new era in the management of type 2 diabetes: Is cardioprotection at long last a reality?

Rossello X., Yellon D.

International journal of cardiology, 2017

Editorial to: "Building a Bridge to the Future of Cardiovascular Drugs and Therapy".

Davidson S.

Cardiovascular drugs and therapy, 2017

Anthracycline Chemotherapy and Cardiotoxicity.

McGowan J., Chung R., Maulik A., Piotrowska I., Walker J., Yellon D.

Cardiovascular drugs and therapy, 2017

Cardio-oncology.

Ghosh A., Walker J.

British journal of hospital medicine (London, England : 2005), 2017

Unique morphological characteristics of mitochondrial subtypes in the heart: the effect of ischemia and ischemic preconditioning.

Kalkhoran S., Munro P., Qiao F., Ong S., Hall A., Cabrera-Fuentes H., Chakraborty B., Boisvert W., Yellon D., Hausenloy D.

Discoveries (Craiova, Romania), 2017

A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.

Bromage D., Taferner S., Pillai M., Yellon D., Davidson S.

PloS one, 2017

Cardio-Oncology - A new subspecialty with collaboration at its heart.

Ghosh A., Walker J.

Indian heart journal, 2017

Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes.

Takov K., Yellon D., Davidson S.

Journal of extracellular vesicles, 2017

2016

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery.

Hausenloy D., Barrabes J., Bøtker H., Davidson S., Di Lisa F., Downey J., Engstrom T., Ferdinandy P., Carbrera-Fuentes H., Heusch G., Ibanez B., Iliodromitis E., Inserte J., Jennings R., Kalia N., Kharbanda R., Lecour S., Marber M., Miura T., Ovize M., Perez-Pinzon M., Piper H., Przyklenk K., Schmidt M., Redington A., Ruiz-Meana M., Vilahur G., Vinten-Johansen J., Yellon D., Garcia-Dorado D.

Basic research in cardiology, 2016

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".

Cabrera-Fuentes H., Aragones J., Bernhagen J., Boening A., Boisvert W., Bøtker H., Bulluck H., Cook S., Di Lisa F., Engel F., Engelmann B., Ferrazzi F., Ferdinandy P., Fong A., Fleming I., Gnaiger E., Hernández-Reséndiz S., Kalkhoran S., Kim M., Lecour S., Liehn E., Marber M., Mayr M., Miura T., Ong S., Peter K., Sedding D., Singh M., Suleiman M., Schnittler H., Schulz R., Shim W., Tello D., Vogel C., Walker M., Li Q., Yellon D., Hausenloy D., Preissner K.

Basic research in cardiology, 2016

Mechanisms of CO

Mercy M., de Leeuw N., Bell R.

Faraday discussions, 2016

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

Tyser R., Miranda A., Chen C., Davidson S., Srinivas S., Riley P.

eLife, 2016

Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment-Elevation Myocardial Infarction and Adverse Left Ventricular Remodeling.

Bulluck H., Rosmini S., Abdel-Gadir A., White S., Bhuva A., Treibel T., Fontana M., Ramlall M., Hamarneh A., Sirker A., Herrey A., Manisty C., Yellon D., Kellman P., Moon J., Hausenloy D.

Circulation. Cardiovascular imaging, 2016

A critical review on the translational journey of cardioprotective therapies!

Rossello X., Yellon D.

International journal of cardiology, 2016

Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model.

Rossello X., Burke N., Stoppe C., Bernhagen J., Davidson S., Yellon D.

Cardiovascular drugs and therapy, 2016

Cardioprotection: The Disconnect Between Bench and Bedside.

Rossello X., Yellon D.

Circulation, 2016

Ultrafast Magnetic Resonance Imaging for Iron Quantification in Thalassemia Participants in the Developing World: The TIC-TOC Study (Thailand and UK International Collaboration in Thalassaemia Optimising Ultrafast CMR).

Abdel-Gadir A., Vorasettakarnkij Y., Ngamkasem H., Nordin S., Ako E., Tumkosit M., Sucharitchan P., Uaprasert N., Kellman P., Piechnik S., Fontana M., Fernandes J., Manisty C., Westwood M., Porter J., Walker J., Moon J.

Circulation, 2016

Automated Extracellular Volume Fraction Mapping Provides Insights Into the Pathophysiology of Left Ventricular Remodeling Post-Reperfused ST-Elevation Myocardial Infarction.

Bulluck H., Rosmini S., Abdel-Gadir A., White S., Bhuva A., Treibel T., Fontana M., Gonzalez-Lopez E., Reant P., Ramlall M., Hamarneh A., Sirker A., Herrey A., Manisty C., Yellon D., Kellman P., Moon J., Hausenloy D.

Journal of the American Heart Association, 2016

Co-dependence of the neural and humoral pathways in the mechanism of remote ischemic conditioning.

Pickard J., Davidson S., Hausenloy D., Yellon D.

Basic research in cardiology, 2016

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure.

Madonna R., Van Laake L., Davidson S., Engel F., Hausenloy D., Lecour S., Leor J., Perrino C., Schulz R., Ytrehus K., Landmesser U., Mummery C., Janssens S., Willerson J., Eschenhagen T., Ferdinandy P., Sluijter J.

European heart journal, 2016

Characterization of the Langendorff Perfused Isolated Mouse Heart Model of Global Ischemia-Reperfusion Injury: Impact of Ischemia and Reperfusion Length on Infarct Size and LDH Release.

Rossello X., Hall A., Bell R., Yellon D.

Journal of cardiovascular pharmacology and therapeutics, 2016

Cangrelor-Mediated Cardioprotection Requires Platelets and Sphingosine Phosphorylation.

Cohen M., Yang X., White J., Yellon D., Bell R., Downey J.

Cardiovascular drugs and therapy, 2016

Contrast-induced nephropathy following angiography and cardiac interventions.

Rear R., Bell R., Hausenloy D.

Heart (British Cardiac Society), 2016

Ischaemic conditioning and reperfusion injury.

Hausenloy D., Yellon D.

Nature reviews. Cardiology, 2016

Quantifying the Area at Risk in Reperfused ST-Segment-Elevation Myocardial Infarction Patients Using Hybrid Cardiac Positron Emission Tomography-Magnetic Resonance Imaging.

Bulluck H., White S., Fröhlich G., Casson S., O'Meara C., Newton A., Nicholas J., Weale P., Wan S., Sirker A., Moon J., Yellon D., Groves A., Menezes L., Hausenloy D.

Circulation. Cardiovascular imaging, 2016

Reducing myocardial infarct size: challenges and future opportunities.

Bulluck H., Yellon D., Hausenloy D.

Heart (British Cardiac Society), 2016

Effect of Remote Ischaemic Conditioning in Oncology Patients Undergoing Chemotherapy: Rationale and Design of the ERIC-ONC Study--A Single-Center, Blinded, Randomized Controlled Trial.

Chung R., Maulik A., Hamarneh A., Hochhauser D., Hausenloy D., Walker J., Yellon D.

Clinical cardiology, 2016

Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism.

Riquelme J., Westermeier F., Hall A., Vicencio J., Pedrozo Z., Ibacache M., Fuenzalida B., Sobrevia L., Davidson S., Yellon D., Sánchez G., Lavandero S.

Pharmacological research, 2016

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.

Cabrera-Fuentes H., Alba-Alba C., Aragones J., Bernhagen J., Boisvert W., Bøtker H., Cesarman-Maus G., Fleming I., Garcia-Dorado D., Lecour S., Liehn E., Marber M., Marina N., Mayr M., Perez-Mendez O., Miura T., Ruiz-Meana M., Salinas-Estefanon E., Ong S., Schnittler H., Sanchez-Vega J., Sumoza-Toledo A., Vogel C., Yarullina D., Yellon D., Preissner K., Hausenloy D.

Basic research in cardiology, 2016

2015

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.

Davidson S., Foote K., Kunuthur S., Gosain R., Tan N., Tyser R., Zhao Y., Graeff R., Ganesan A., Duchen M., Patel S., Yellon D.

Cardiovascular research, 2015

From Protecting the Heart to Improving Athletic Performance - the Benefits of Local and Remote Ischaemic Preconditioning.

Sharma V., Marsh R., Cunniffe B., Cardinale M., Yellon D., Davidson S.

Cardiovascular drugs and therapy, 2015

The addition of CO₂ to four superbase ionic liquids: a DFT study.

Mercy M., Taylor S., Jacquemin J., Hardacre C., Bell R., De Leeuw N.

Physical chemistry chemical physics : PCCP, 2015

The Effect of Remote Ischemic Conditioning and Glyceryl Trinitrate on Perioperative Myocardial Injury in Cardiac Bypass Surgery Patients: Rationale and Design of the ERIC-GTN Study.

Hamarneh A., Sivaraman V., Bulluck H., Shanahan H., Kyle B., Ramlall M., Chung R., Jarvis C., Xenou M., Ariti C., Cordery R., Yellon D., Hausenloy D.

Clinical cardiology, 2015

A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development.

Payne S., Burney M., McCue K., Popal N., Davidson S., Anderson R., Scambler P.

Developmental biology, 2015

The pleiotropic effects of metformin: time for prospective studies.

Bromage D., Yellon D.

Cardiovascular diabetology, 2015

Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload.

Sado D., Maestrini V., Piechnik S., Banypersad S., White S., Flett A., Robson M., Neubauer S., Ariti C., Arai A., Kellman P., Yamamura J., Schoennagel B., Shah F., Davis B., Trompeter S., Walker M., Porter J., Moon J.

Journal of magnetic resonance imaging : JMRI, 2015

TPC1 Knockout Knocks Out TPC1.

Hooper R., Churamani D., Davidson S., Lin-Moshier Y., Walseth T., Patel S., Marchant J.

Molecular and cellular biology, 2015

Plasma exosomes protect the myocardium from ischemia-reperfusion injury.

Vicencio J., Yellon D., Sivaraman V., Das D., Boi-Doku C., Arjun S., Zheng Y., Riquelme J., Kearney J., Sharma V., Multhoff G., Hall A., Davidson S.

Journal of the American College of Cardiology, 2015

Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.

Kapustin A., Chatrou M., Drozdov I., Zheng Y., Davidson S., Soong D., Furmanik M., Sanchis P., De Rosales R., Alvarez-Hernandez D., Shroff R., Yin X., Muller K., Skepper J., Mayr M., Reutelingsperger C., Chester A., Bertazzo S., Schurgers L., Shanahan C.

Circulation research, 2015

Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial.

Candilio L., Malik A., Ariti C., Barnard M., Di Salvo C., Lawrence D., Hayward M., Yap J., Roberts N., Sheikh A., Kolvekar S., Hausenloy D., Yellon D.

Heart (British Cardiac Society), 2015

Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction.

White S., Frohlich G., Sado D., Maestrini V., Fontana M., Treibel T., Tehrani S., Flett A., Meier P., Ariti C., Davies J., Moon J., Yellon D., Hausenloy D.

JACC. Cardiovascular interventions, 2015

UK-Russia Researcher Links Workshop: extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 March 2015.

Kapustin A., Kalinina N., Lopatina T., Davidson S., Iraci N., Tamkovich S., Smyth L., Ter-Ovanesyan D., Evtushenko E., Savelieva O., Bertazzo S., Aushev V., Dragovic R., Gracia T., Heck M., Parfyonova Y., Shanahan C., Tkachuk V.

Journal of extracellular vesicles, 2015

2014

A retrospective analysis of myocardial preservation techniques during coronary artery bypass graft surgery: are we protecting the heart?

Candilio L., Malik A., Ariti C., Khan S., Barnard M., Di Salvo C., Lawrence D., Hayward M., Yap J., Sheikh A., McGregor C., Kolvekar S., Hausenloy D., Yellon D., Roberts N.

Journal of cardiothoracic surgery, 2014

ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies.

Lecour S., Bøtker H., Condorelli G., Davidson S., Garcia-Dorado D., Engel F., Ferdinandy P., Heusch G., Madonna R., Ovize M., Ruiz-Meana M., Schulz R., Sluijter J., Van Laake L., Yellon D., Hausenloy D.

Cardiovascular research, 2014

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

Chouchani E., Pell V., Gaude E., Aksentijević D., Sundier S., Robb E., Logan A., Nadtochiy S., Ord E., Smith A., Eyassu F., Shirley R., Hu C., Dare A., James A., Rogatti S., Hartley R., Eaton S., Costa A., Brookes P., Davidson S., Duchen M., Saeb-Parsy K., Shattock M., Robinson A., Work L., Frezza C., Krieg T., Murphy M.

Nature, 2014